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Mohs vs WLE for Extramammary Paget's Disease (EMPD)

Zhang M, Gao X, Gao T, et al.
Dermatologic Surgery (2026)

JC: February 2023

This study compared Mohs micrographic surgery (MMS) with wide local excision (WLE) for the treatment of extramammary Paget's disease (EMPD). MMS demonstrated lower recurrence rates than WLE while preserving more tissue, supporting its role as a preferred surgical approach for this challenging condition.

Take-Home Messages

  • •Mohs surgery offers superior margin control and lower recurrence rates compared to WLE for EMPD.
  • •Given the subclinical spread typical of EMPD, complete margin assessment with MMS is particularly advantageous.

Topic

Mohs Technique & Outcomes

Mohs micrographic surgery indications, outcomes, and procedural refinements

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Mohs Technique

Abstract

This retrospective study assessed the effectiveness of Mohs micrographic surgery (MMS) combined with adjuvant radiotherapy for the treatment of extramammary Paget's disease (EMPD). This retrospective study included 87 patients with pathologically confirmed EMPD and complete follow-up data who were treated at the Radiation Therapy Department of Peking University First Hospital between January 2012 and December 2021. The surgical approach for the primary lesion involved MMS, followed by postope...

Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.