This multi-factor analysis identified key risk factors for surgical site infection (SSI) in dermatologic surgery procedures. The study analyzed patient, procedural, and wound-related variables that predict SSI development, providing evidence-based guidance for infection prevention strategies. The findings have practical implications for perioperative antibiotic use and wound management protocols in dermatologic surgery.

Key SSI risk factors in dermatologic surgery include lower extremity location, flap/graft closures, and patient immunosuppression.

Prophylactic antibiotics should be targeted based on identified risk factors rather than administered universally.

Wound location below the knee and complex reconstructions are among the strongest predictors of SSI.