This study evaluated outcomes of invasive melanoma of the head and neck treated with Mohs micrographic surgery. The analysis assessed local recurrence, disease-free survival, and melanoma-specific survival in this challenging anatomical region where tissue conservation is critical. Results demonstrated favorable outcomes with Mohs for head and neck melanoma, supporting its use as an effective surgical approach in this anatomically complex location.

Mohs surgery for head and neck melanoma demonstrates excellent local control with tissue-sparing benefits.

MART-1 immunostaining is essential for accurate margin assessment of melanoma during Mohs surgery.

Head and neck melanoma treated with Mohs should be combined with appropriate staging (SLNB) and surveillance protocols.