This study assessed the utility of baseline imaging with ultrasound and FDG-PET/CT in newly diagnosed Merkel cell carcinoma. The findings demonstrated that baseline imaging can detect occult nodal and distant metastases, informing staging accuracy and treatment planning in MCC.

Baseline imaging with PET/CT and ultrasound in MCC can identify occult metastases and improve initial staging accuracy.

Early detection of nodal involvement through baseline imaging may alter management and improve outcomes in Merkel cell carcinoma.