This study compared high-risk prognostic tumor features of cutaneous SCC in organ transplant recipients (OTRs) versus the general population. OTRs demonstrated a higher prevalence of adverse histologic features including perineural invasion and poor differentiation, supporting the need for more aggressive surveillance and treatment strategies.

SCC in organ transplant recipients more frequently exhibits high-risk histologic features compared to immunocompetent patients.

Transplant recipients with SCC may benefit from closer surveillance and a lower threshold for adjuvant treatment due to their higher-risk tumor biology.