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cSCC in Transplant Recipients - Rates of Second Tumor, Metastasis, and Death (JAMA Derm)

Gjersvik P, Falk RS, Roscher I, et al.
JAMA Dermatology (2023)

Open AccessJC: October 2023

This JAMA Dermatology study quantified the rates of second primary tumors, metastasis, and death in transplant recipients with cutaneous SCC. The data revealed substantially higher rates of all adverse outcomes compared to the general population, reinforcing the aggressive nature of cSCC in immunosuppressed patients.

Take-Home Messages

  • •Transplant recipients with cSCC face significantly elevated risks of second tumors, metastasis, and disease-specific mortality.
  • •Multidisciplinary management and enhanced surveillance protocols are critical for transplant recipients diagnosed with cSCC.
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Topic

Transplant & Immunosuppression

Skin cancer in organ transplant recipients, immunosuppression management

Abstract

Cutaneous squamous cell carcinoma (cSCC) may occur with multiple primary tumors, metastasize, and cause death both in immunocompetent and immunosuppressed patients. To study the rates of second cSCC, metastasis, and death from cSCC in patients with and without organ transplant-associated immunosuppressive treatment. This population-based, nationwide cohort study used Cancer Registry of Norway data from 47 992 individuals diagnosed with cSCC at 18 years or older between January 1, 1968,...

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Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.