This multicenter prospective study evaluated pain levels associated with lidocaine injection during subsequent stages of Mohs surgery. Results showed that patients experience progressively less pain with each subsequent injection, likely due to residual anesthesia and tissue changes from prior stages.

Patients should be reassured that lidocaine injections during later Mohs stages are typically less painful than the initial injection.

Residual local anesthesia from prior stages reduces the discomfort of re-injection during multi-stage Mohs procedures.