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AK Field Therapy - Updated Evidence and Approaches

Kazemi T, Younesi V, Jadidi-Niaragh F, et al.
Dermatologic Surgery (2016)

JC: March 2023

This review provided updated evidence on actinic keratosis field therapy approaches including topical fluorouracil, imiquimod, ingenol mebutate, photodynamic therapy, and combination strategies. The review synthesized recent trial data to guide clinicians in selecting the most effective field therapy for individual patient profiles.

Take-Home Messages

  • •AK field therapy reduces the overall burden of actinic damage and may decrease the risk of progression to invasive SCC.
  • •Selection of field therapy should be individualized based on AK burden, location, patient tolerance, and prior treatment response.

Topic

Chemoprevention

Nicotinamide, retinoids, immunotherapy for cancer prevention

Abstract

In spite of specific immune effector mechanisms raised against tumor cells, there are mechanisms employed by the tumor cells to keep them away from immune recognition and elimination; some of these mechanisms have been identified, while others are still poorly understood. Manipulation or augmentation of specific antitumor immune responses are now the preferred approaches for treatment of malignancies, and traditional therapeutic approaches are being replaced by the use of agents which potenti...

Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.