This study evaluated the safety of watchful waiting after biopsy for SCC in situ, examining recurrence and progression rates in patients who did not undergo immediate definitive treatment. The results provided data on the natural history of incompletely excised SCCis and guided decision-making about observation versus treatment.

Watchful waiting after biopsy of SCC in situ may be acceptable in select low-risk cases, though close monitoring is essential.

Definitive treatment of SCCis should remain the standard approach, with observation reserved for patients in whom surgical morbidity outweighs oncologic risk.