This study evaluated the subsequent skin cancer risk in patients diagnosed with atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS). Patients with AFX/PDS demonstrated an elevated risk of developing additional skin cancers, supporting the need for long-term dermatologic surveillance.

Patients with AFX or pleomorphic dermal sarcoma have an increased risk of developing subsequent skin cancers and require ongoing surveillance.

The elevated skin cancer risk in AFX/PDS patients likely reflects shared risk factors including UV exposure and immunosuppression.