This systematic review evaluated treatment approaches for desmoplastic trichoepithelioma, a benign but locally aggressive adnexal tumor that can mimic BCC. Mohs micrographic surgery was identified as the treatment of choice due to its ability to provide complete margin assessment and minimize recurrence.

Mohs surgery is the preferred treatment for desmoplastic trichoepithelioma due to superior margin control and low recurrence rates.

Accurate histologic differentiation of desmoplastic trichoepithelioma from morpheaform BCC is critical for appropriate treatment planning.