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Sebaceous Carcinoma - CK7 as Immunohistochemical Marker in Mohs

Brady KL, Hurst EA
Dermatologic Surgery (2017)

JC: May 2024

This study evaluated CK7 as an immunohistochemical marker for sebaceous carcinoma during Mohs micrographic surgery. CK7 demonstrated utility in identifying residual sebaceous carcinoma on frozen sections, improving the accuracy of margin assessment for this aggressive adnexal tumor.

Take-Home Messages

  • •CK7 immunostaining on frozen sections improves margin assessment accuracy during Mohs surgery for sebaceous carcinoma.
  • •Incorporating CK7 into the Mohs histotechnique for sebaceous carcinoma can help ensure complete tumor clearance.

Topic

Rare & Special Tumors

DFSP, AFX, sebaceous carcinoma, EMPD, MAC, and other rare entities

Related MohsPedia Articles

Tumor DfspTumor Afx PdsTumor Sebaceous CaTumor EmpdTumor Mac

Abstract

Sebaceous carcinoma is a rare and potentially aggressive adnexal neoplasm with historic data indicating high rates of recurrence, metastasis, and cancer-specific mortality. To evaluate the incidence of local recurrence, metastasis, disease-specific mortality, and all-cause mortality and to identify work-up approaches. Retrospective review of patients with sebaceous carcinoma treated with Mohs micrographic surgery between 2001 and 2013 at one institution. Thirty-seven patients had 45 sebaceous...

Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.