This review summarized the management of malignant adnexal tumors including microcystic adnexal carcinoma, sebaceous carcinoma, and other rare cutaneous appendageal neoplasms. The review highlighted the role of Mohs surgery, the importance of immunohistochemistry, and the need for multidisciplinary care.

Malignant adnexal tumors benefit from Mohs surgery due to their tendency for subclinical extension and perineural invasion.

Immunohistochemistry plays a critical role in the accurate diagnosis and margin assessment of adnexal carcinomas.