This study catalogued and characterized histologic artifacts and mimickers encountered during Mohs frozen section interpretation. These 'histologic hitchhikers' include various structures and artifacts that can be confused with tumor, potentially leading to false-positive margin readings and unnecessary additional stages. The study provides a visual reference guide for Mohs surgeons to improve frozen section interpretation accuracy.

Common histologic mimickers in Mohs include follicular structures, eccrine glands, and inflammatory infiltrates that can mimic BCC.

Awareness of tissue processing artifacts and normal anatomical structures is essential for accurate frozen section interpretation.

This visual reference guide can serve as a quality improvement tool for Mohs surgeons and trainees.