This study evaluated when radiologic imaging is indicated for high-risk cutaneous SCC and which modalities are most appropriate. The review provided evidence-based recommendations for imaging utilization based on tumor risk factors, clinical staging, and suspicion for nodal or distant metastasis.

Imaging for high-risk cSCC should be guided by specific clinical and histologic risk factors rather than applied routinely.

Ultrasound, CT, and PET/CT each have distinct roles in staging high-risk cSCC depending on the clinical scenario.