This study compared Mohs surgery with wide local excision for primary high-stage cutaneous squamous cell carcinoma, evaluating recurrence rates, survival, and margin status. Mohs surgery demonstrated favorable outcomes with lower recurrence rates and better tissue conservation, supporting its use even for high-stage cSCC.

Mohs surgery achieves lower recurrence rates than wide local excision for high-stage cSCC while preserving more tissue.

High-stage cSCC is an appropriate indication for Mohs surgery, particularly on the head and neck where tissue conservation is paramount.