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DFSP Treated with Mohs Micrographic Surgery (Outcomes Analysis)

Jung JW, Zhang HS, Nam KA, et al.
Dermatologic Surgery (2025)

JC: March 2026

This outcomes analysis evaluated Mohs micrographic surgery for dermatofibrosarcoma protuberans (DFSP), assessing recurrence rates and margin clearance. The data confirmed excellent oncologic outcomes with Mohs for DFSP, with significantly lower recurrence compared to standard excision.

Take-Home Messages

  • •Mohs surgery is the treatment of choice for DFSP, with significantly lower recurrence rates than standard wide local excision.
  • •Complete peripheral and deep margin assessment with Mohs is particularly important given DFSP's tendency for irregular subclinical extension.

Topic

Rare & Special Tumors

DFSP, AFX, sebaceous carcinoma, EMPD, MAC, and other rare entities

Related MohsPedia Articles

Tumor DfspTumor Afx PdsTumor Sebaceous CaTumor EmpdTumor Mac

Abstract

The optimal surgical margin for wide local excision (WLE) of dermatofibrosarcoma protuberans (DFSP) remains controversial. This study aimed to determine appropriate WLE margins through the analysis of Mohs micrographic surgery (MMS) outcomes. We retrospectively analysed 177 DFSP patients treated with MMS from 2003 to 2023. Logistic regression identified factors associated with histologically clear margins ≥1 cm. Receiver operating characteristic analysis determined a tumour size cutoff...

Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.