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Concordance Between a Mohs Micrographic Surgeon and Dermatopathologist on Margin Status for Melanoma In Situ and the Role of Immunohistochemical Stains

Yanes AF, Bougrine A, Piris A, et al.
Dermatologic Surgery (2025)

JC: October 2025

This study evaluated the concordance between Mohs surgeons and dermatopathologists in assessing melanoma margin status on frozen sections. High concordance rates were observed, supporting the competency of Mohs surgeons in independent melanoma margin interpretation when using appropriate immunostains.

Take-Home Messages

  • •Mohs surgeons demonstrate high concordance with dermatopathologists in melanoma margin assessment on immunostained frozen sections.
  • •This concordance data supports the competency of fellowship-trained Mohs surgeons to independently interpret melanoma margins.

Topic

Margin Assessment & IHC

Frozen section interpretation, MART-1, immunohistochemistry stains

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Abstract

Few studies have examined the concordance between Mohs surgeons and dermatopathologists' interpretation of margin status during Mohs micrographic surgery (MMS) for melanoma in situ (MIS). The objectives of this study were to determine the concordance between a Mohs surgeon and dermatopathologist on margin status for MIS and to analyze the role of immunohistochemical stains during Mohs surgery. This was a prospective study at 1 academic center of patients undergoing Mohs surgery for MIS. The M...

Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.