This study differentiated between satellitosis and in-transit metastasis in cutaneous squamous cell carcinoma, analyzing their distinct clinicopathologic features and prognostic implications. The findings provided clarity on the classification and management implications of these two forms of locoregional tumor spread.

Distinguishing satellitosis from in-transit metastasis in cSCC has important prognostic and staging implications.

Both satellitosis and in-transit metastasis indicate aggressive tumor biology and should prompt evaluation for systemic disease.