This study examined the clinical significance and prognostic implications of tumor upstaging in invasive melanoma, where definitive excision reveals a higher T-stage than the initial biopsy. The analysis addressed how upstaging affects management decisions including the need for SLNB and adjuvant therapy.

Melanoma upstaging at definitive excision can alter management including SLNB candidacy and adjuvant treatment eligibility.

Clinicians should be prepared to re-evaluate the treatment plan when upstaging occurs after initial melanoma biopsy.