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Does PDL / Pulsed Dye Laser Decrease Keratinocyte Cancer Risk?

Hu J, Benson T, Aleissa S, et al.
March 2026 Journal Club (KBURK@nm.org (2026)

JC: March 2026

This study investigated whether pulsed dye laser (PDL) treatment can reduce the risk of developing keratinocyte carcinomas (BCC and SCC). The analysis evaluated the chemopreventive potential of PDL through its effects on photodamaged skin vasculature and precancerous lesions.

Take-Home Messages

  • •Pulsed dye laser treatment shows potential as a chemopreventive strategy for keratinocyte cancers by targeting photodamaged skin.
  • •Further controlled studies are needed to establish the long-term efficacy of PDL for skin cancer prevention.
PubMed →DOI →

Topic

Chemoprevention

Nicotinamide, retinoids, immunotherapy for cancer prevention

Abstract

Keratinocyte carcinomas (KCs) are the most common cancers in the United States. Despite existing preventative strategies, their incidence continues to rise, highlighting a need for better intervention. The pulsed dye laser (PDL) has a myriad of medical indications but has not been studied in skin cancer prevention. The objective of this study was to assess the effect of PDL treatment on subsequent facial KC development. A retrospective cohort study was conducted on patients with a history of ...

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Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.