This study evaluated oncologic outcomes for invasive SCC with a clinically resolved biopsy site managed with watchful waiting rather than immediate definitive excision. The data provided evidence on the safety of observation in select cases where the biopsy appeared to completely remove the tumor.

Watchful waiting may be an acceptable approach for select invasive SCCs with clinically resolved biopsy sites, though careful patient selection is critical.

Close clinical follow-up is mandatory when pursuing observation for invasive SCC to detect early recurrence.