This study demonstrated that nevus-associated acral melanoma has lower rates of recurrence and mortality compared to de novo acral melanoma. The findings suggest that the biologic behavior and prognosis of acral melanoma may differ based on its association with a precursor nevus.

Nevus-associated acral melanoma carries a better prognosis than de novo acral melanoma, with lower recurrence and mortality rates.

The distinction between nevus-associated and de novo acral melanoma may have implications for prognostic counseling and surveillance intensity.