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Impact of Two-Octyl Cyanoacrylate (Tissue Adhesive) on Surgical Site Infections After Lower-Extremity Dermatologic Procedures

Ingrasci G, Miller A, Brian Jiang SI
Dermatologic Surgery (2025)

JC: January 2026

This study evaluated the impact of 2-octyl cyanoacrylate (tissue adhesive) on surgical site infection rates following lower extremity dermatologic surgery. The analysis assessed whether tissue adhesive application provides a protective barrier against wound contamination in this high-infection-risk anatomic location.

Take-Home Messages

  • •Tissue adhesive application may help reduce surgical site infection risk in lower extremity surgery by providing a protective wound barrier.
  • •2-Octyl cyanoacrylate offers potential dual benefits of wound closure and infection prevention in lower extremity dermatologic procedures.

Topic

Perioperative Safety

Infection prevention, antibiotics, surgical safety protocols

Abstract

Surgical site infections after lower extremity dermatologic procedures increase morbidity, recovery time, and health care costs. This study examined whether the introduction of a skin adhesive closure method influenced infection rates and antibiotic use over a 10-year period. The authors performed a single-center retrospective cohort analysis of adult patients undergoing lower-leg dermatologic surgery between 2013 and 2023. The 3 cohorts were procedures before adhesive availability closed wit...

Literature review only. This summary is an editorial interpretation and may not reflect the complete findings of the original publication. Always refer to the full-text article for clinical decision-making.